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Simultaneous measurement of TOC and conductivity to analyze non-conductive organic substances in cleaning agents.

[Application Note] A New Perspective on Cleaning Validation: Residual Assessment of Cleaning Agents through Simultaneous Measurement of TOC and Conductivity

In the pharmaceutical industry, cleaning validation of manufacturing equipment is a crucial element of quality control. In cleaning validation, conductivity is useful for detecting residual cleaning agents, but it cannot accurately assess the concentration of organic substances. TOC is very useful in the cleaning evaluation of manufacturing equipment because it can detect both types of organic substances (conductive and non-conductive). Particularly in cases where non-conductive organic substances are present, relying solely on conductivity for cleaning evaluation increases the risk of missing organic contamination.

  • Analytical Equipment and Devices

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